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Akt activation, monitored by phosphorylation of its substrate PRAS40 at T246, inhibits the TSC1 TSC2 complex by phosphorylation at T1462 (ref. 22); and TSC1 TSC2 inhibits mTORC1 activity22, as monitored by the phosphorylation of its substrates PRAS40 S183 and p70 S6K T389, and the p70 S6K substrate mTOR S2448 (ref. 22).
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With a combined record of 16 26, the NFC East is a struggling division. Whilst a wild card spot is unachieveable, each East team is able to take comfort in the fact that they are as bad as each other. With this division, the team with the fewest losses rather than the most wins is likely to make the playoffs..
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